The guilt and pressure weighs heavily on twilight, with no word from any of the other princesses. And discords powers compleatly useless against the virus, the survival of ponykind lies all on Twilight. The only ones of the mane six shes heard from is Rainbow Dash and Rarity. Discord is is disarray trying to reverse the effects on fluttershy, but shes is far too gone and deteriorating fast in a room sealed in twilights castle. Twilight even sent word to Zecora, but no response.
Tempest has no idea how to comfort anyone, as she does not address such emotions, but she can be a good shoulder to cry on.